Case studies

Case study 1

Our client required the synthesis of a library of 18 heteroaromatic compounds, which all had a common branch point.
 
We undertook an 8 week FTE project to synthesize this library.
 
All compounds were synthesized in the time allotted.
 
(Small pharma company)
 
 
Case Study 2
 
Our client required the synthesis of an ultra-pure α-amino acid derivative on 1 Kg scale (99.7% purity, ee > 99.5%).
 
We undertook the synthesis as a customer synthesis project using ‘off-patent’ hydrogenation catalysts to invoke the required enantioselectivity.  An optimized, controlled crystallization gave the required purity level.
 
The α-amino acid derivative was synthesized on time and within the required specification.
 
(Large pharma company)
 
 
 Case Study 3
 
Our client required the synthesis of 2g of a hard to synthesise nucleoside.
 
We undertook a contract synthesis.
 
Attempted synthesis using literature routes all failed.
 
We found a novel route to the nucleoside and supplied the customer with the material in the required specification.
 
(Academic Institution)
 
 
Case Study 4
 
Our client required the synthesis of 2 novel bicyclic compounds (10g of each).
 
Only limited literature was available in the area.
 
Initial routes failed to give the compounds but perseverance paid off and a novel route was found to both compounds.
 
(Large pharma company)
 
 
Case Study 5
 
Our client required the identification and full characeterisation of a process impurity seen by HPLC.
 
Using our state-of-the-art LC-MS we identified the impurity.
 
Using an alternative route we synthesized the impurity and subsequently fully characterized the compound.
 
(Medium biotechnology company)